Horst Kunhardt, Erich Wühr
Kommunale Gesundheitsförderung mit System
Bavarian Journal of Applied Sciences, vol. 1, no. 1, pp. 50-61
Diese Monografie basiert auf unserem derzeitigen Wissens- und Erfahrungsstand. Sie klärt zunächst die Begriffe und grenzt sie gegeneinander ab. Anschließend beschreibt sie die relevanten internationalen und nationalen Rahmenbedingungen der kommunalen Gesundheitsförderung.
Das Kernstück der Monografie ist die Beschreibung einer idealen kommunalen Gesundheitsförderung, die der Analyse der Ausgangssituation in einer Kommune oder Region ebenso dient wie der Ausrichtung der operativen Planung und Umsetzung sowie der Evaluation und ständigen Verbesserung.
Die Darstellung des Forschungsfelds „Kommunale Gesundheitsförderung“ sowie die verwendeten Quellen schließen die Monografie ab.
Die Monografie dient somit als Handreichung für politische und kommunale Entscheidungs- und Leistungsträger. Damit können sich Kommunen und Regionen zu Gesundheitskommunen bzw. Gesundheitsregionen entwickeln, die ihren Bürgern und Gästen in den sozialen Settings der Kommune oder Region (Behörden, Schulen, Unternehmen, Vereinen und so weiter) eine koordinierte und systematische kommunale Gesundheitsförderung als nachhaltig ausgelegten Standortfaktor für bestmögliche Lebensbedingungen und bestmögliche Lebensqualität anbieten.
This monography is based on our present status of knowledge and experience. It starts with clearing and defining of the basic terms. Then it describes the relevant national and international frame conditions of municipal health promotion.
The core of the monography is a description of the ideal municipal health promotion according to our actual knowledge and experiences which is helpful for the analysis of the starting status of health promotion in a certain community or region as well as for the orientation of operative planning, implementation, evaluation and continuous improvement.
The presentation of the research field „municipal health promotion“ and of the sources we used is completing the monography.
Thus the monography is serving as a handout for politicians and decision-makers in communities. This information helps that communities and regions can develop into health communities and health regions which offer a coordinated and systematic health promotion to their citizens and guests in different social settings (for example authorities, schools, companies). In this way the health promoting community or region can present itself as a habitat with the best possible living conditions and quality of life to their inhabitants and visitors.
Die Zukunftsorientierung der deutschen Pflegewissenschaft an der Schnittstelle von Alter(n) und Pflege
Ein Plädoyer zur Konturierung pflegewissenschaftlicher Identität
Pflegewissenschaft, vol. 17, no. 2, pp. 103-115
Kunst als Erfahrung
Ausgewählte Grundgedanken John Deweys als Argumente für ästhetische Pflegebildungsprozesse
PADUA - Die Fachzeitschrift für Pflegepädagogik, Patientenedukation und -bildung, no. 1, pp. 12-18
DigitalGesundEuropan Campus Rottal-Inn
Beitrag (Sammelband oder Tagungsband)
D. Polterauer, P. Friedrich, Thomas Spittler, B. Wolf
Rehabilitation´s Aftercare by COMES®
Proceedings of the 1st European Congress on e-Cardiology & e-Health, Selected Abstracts (October 29-31, 2014; Bern, Switzerland)
, no. 2_suppl, pp. 38-44
Purpose: In Germany the demand of medical rehabilitation increases steadily. Nevertheless, the duration of rehabilitation is limited to three weeks, making an efficient and successful post-rehabilitative aftercare essential. Therefore, a telematic system called COMES® was developed at the Heinz Nixdorf Lehrstuhl der Technischen Universität München.
One of the strength of COMES® is the possibility of therapy support, for example when suffering from cardiovascular disease. The physician sets a therapy goal and COMES® supports the patient by motivation feedback reaching that goal.
Methods: For evaluating COMES® motivation feedback a field tests was designed and conducted. Therefore, ten study participants from the age of 40 to 66 were equipped with the COMES®-System. While the first week represents the baseline, the second week serves as getting familiarized and the third week shows participants’ activity with motivation messages.
For statistical analysis nonparametric statistics, the Wilcoxon-Mann-Whitney test, were used, inter alia due to the small sample size.
Results: All the participants significantly increased their physical activity, with a p value of p = 0.008. During baseline week the mean steps per day were about 4,690 with a standard deviation of 1,625 steps per day. After third week the mean daily number of steps increased by 2,240 with a standard deviation of 1,970 steps per day.
Conclusion: COMES® enables both physicians and patients to maintain and individually adjust therapy guidelines for hypertonia. Thus, it leads to a consequent accomplishment of the after-care targets and prevents a creeping demotivation. First studies show, that there is a significant increase of participants’ physical activity due to the COMES® motivation messages.
Melanie Kappelmann-Fenzl, Sylvia Hagemann, B. Velimirov, I. Hassl, A. Ellinger, L. Stöger
DNA-bearing membrane vesicles produced by Ahrensia kielensis and Pseudoalteromonas marina
Journal of Basic Microbiology, vol. 54, no. 10, pp. 1062-1072
Outer membrane vesicles (OMVs) derived from the alphaproteobacterium Ahrensia kielensis and from Pseudoalteromonas marina, a gammaproteobacterium, were sampled from liquid cultures in order to extract the MV-associated DNA, establish a shotgun library, and sequence randomly chosen clones to determine the origins of their DNA. We show that OMVs from A. kielensis and from P. marina both harbour DNA larger than 20 or 30 kbp. Transmission electron microscopical inspection of OMVs of A. kielensis and P. marina showed two types of vesicles: bilayered OMVs with a diameter between 30 and 250 nm and double bilayered OMVs ranging between 80 and 200 nm. Bilayered OMVs are either characterized by the presence of a large electron-dense substance or are elctron translucent. Double bilayered OMVs contained an electron dense substance in the core region surrounded by the second bilayer. 30,094 bp of the genome from OMV of A. kielensis and 45,981 bp of that from P. marina were sequenced. The results indicated that all sequences were single copy and that all sequences, with one exception, were similar to prokaryotic sequences, inserted viral sequences were not detected.
S. Kuphal, Melanie Kappelmann-Fenzl, A. Bosserhoff
AP-1/c-Jun transcription factors: regulation and function in malignant melanoma
European Journal of Cell Biology, vol. 93, no. 1-2, pp. 76-81
Malignant melanoma is an aggressive form of skin cancer with an increasing incidence worldwide. One way to address the pathology of the disease is through molecular research. In addition to the analysis of melanoma-relevant signaling pathways, the investigation of important transcription factors is a fundamental objective. The AP-1 transcription factor family is known to play an important role in melanoma progression and development. The AP-1 family member c-Jun is highly expressed and active in melanoma cells, and the mechanisms and signaling pathways regulating c-Jun protein are diverse. In addition to the common regulation and activation of c-Jun by mitogen-activated protein kinases (MAPKs), there are several other signaling pathways and interactions leading to c-Jun protein expression and thus AP-1 activation. In malignant melanoma, and many other cancer types, c-Jun has mainly oncogenic functions; however, other AP-1 proteins also have anti-oncogenic roles. Interestingly, several studies have revealed that a strong AP-1 activity in melanoma mainly depends on c-Jun. Recently, it has also been shown that the c-Jun protein is regulated and activated by several other mechanisms, including miRNAs and the cytoskeleton. In summary, there are a variety of mechanisms underlying the induction of c-Jun protein expression and activity leading to tumor progression and development, and this diverse regulatory machinery is due to the heterogeneity of different tumor types, particularly in malignant melanoma.
D. Kartal, K. Fodor, S. Yoo, E. Alisic, L. Soler, Agnes Nocon, J. Unterhitzenberger, S. Leistner, M. Milosavljevic, J. White, C.-Y. Chou
Is traumatic stress research global? A bibliometric analysis
European Journal of Psychotraumatology, vol. 5
S. Kuphal, L. Vardimon, Melanie Kappelmann-Fenzl, G. Meister, A. Bosserhoff
MicroRNA miR-125b controls melanoma progression by direct regulation of c-Jun protein expression
Oncogene, vol. 32, no. 24, pp. 2984-2991
A fundamental event in the development and progression of malignant melanoma is the deregulation of cancer-relevant transcription factors. We recently showed that c-Jun is a main regulator of tumor progression in melanoma and thus the most important member of the AP-1 transcription factor family for this disease. Interestingly, we revealed that c-Jun expression was regulated on the post-transcriptional level and therefore speculated that miRNAs could be involved in c-Jun regulation. We determined seed sequences for miR-125b and miR-527 in the coding region of c-Jun mRNA that hints at the direct involvement of miRNA-dependent regulation on the protein level. We found that the expression of miR-125b was significantly reduced in malignant melanoma cell lines and tissue samples compared with melanocytes, whereas miR-527 remained unchanged. In further functional experiments, treatment of melanoma cells with pre-miR-125b resulted in strong suppression of cellular proliferation and migration, supporting the role of miR-125b in melanoma. In addition, transfection of pre-miR-125b led to strong downregulation of c-Jun protein but not mRNA expression in melanoma cells. Luciferase assays using reporter plasmids containing the miR-125b seed sequence in the luciferase coding region confirmed the direct interaction with miR-125b. Furthermore, immunoprecipitation of Ago-2 revealed that c-Jun mRNA accumulated in the RNA-induced silencing complex after pre-miR-125b transfection in melanoma cells. In summary, we identified an important role for miR-125b in malignant melanoma. Moreover, we demonstrated post-transcriptional regulation of c-Jun by this miRNA and showed that c-Jun is a main mediator of the effects of miR-125b on melanoma cells.