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Suche nach „[Nocon] [Agnes]“ hat 50 Publikationen gefunden
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    Agnes Nocon, T. Brückl, P. Zimmermann, R. Lieb, H.-U. Wittchen

    Specific vulnerability and risk factors for the onset of panic disorder, agoraphobia and other phobias

    [Congress Abstract; 25th Symposium of the AGNP; Munich; October, 3-6, 2007]

    Pharmacopsychiatry, vol. 40, no. 5

    Abstract anzeigen

    Background: On the background of the ongoing debate whether agoraphobia is a conditioned reaction to biologically elicited panic attacks as proposed by Donald Klein, or whether agoraphobia is accompanied by panic attacks just like other phobias as suggested by Isaac Marks, we aim to study the common and the specific nature of vulnerability/risk factors of panic disorder [PD], agoraphobia [AG], social [SOC] and specific phobia [SPE]. Method: Analyses are based on 3021 participants from a 10-year prospective-longitudinal community survey (14-24 years old at baseline). Lifetime DSM-IV diagnoses and syndromes were assessed via standardized M-CIDI interview. Vulnerabilities in three domains (socio-demographic, family and behavioral-emotional) were assessed. Results: (1) Subjects with PD, SOC and SP were at higher risk for AG, and subjects with AG and SP were at higher risk for panic attacks/disorder. 2) All syndromes were associated with behavioral inhibition (fear). 3) Only phobias, but not PD, were associated with temperament (harm avoidance), behavioral inhibition (social), gender, parental mood disorder, and separation from parents. 4) Parenting style (rejection) was associated to SOC and SP, but not to AG or PD. Discussion: There is some evidence that phobias (particularly AG and SP) are similar with respect to anxiety comorbidity patterns and associations with socio-demographic, family and behavioral-emotional factors, and that these associations are not accounted for by anxiety comorbidity. Risk factors for PD might be rather unspecific and accounted for by comorbid phobias.

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    T. Brückl, P. Zimmermann, Agnes Nocon, H.-U. Wittchen, R. Lieb, M. Ising

    Birth complications increase the liability for depression according to trauma

    [Abstract]

    Nervenarzt, vol. 78, no. Supplement 2

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    T. Brückl, P. Zimmermann, Agnes Nocon, H.-U. Wittchen, R. Lieb, M. Ising

    Exposure to natal complications influences vulnerability for depression under traumatic conditions

    Abstractband zum Institutssymposium des Max-Planck-Instituts für Psychiatrie (24.-25.07.2007), München

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    Agnes Nocon, H.-U. Wittchen, K. Beesdo, T. Brückl, M. Hofler, H. Pfister, P. Zimmermann, R. Lieb, M. Ising

    Differential familial liability of panic disorder and agoraphobia

    Abstractband zum Institutssymposium des Max-Planck-Instituts für Psychiatrie (24.-25.07.2007), München

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    R. Lieb, L. Schwender, Agnes Nocon, H. Pfister, H.-U. Wittchen

    Natural course of obsessive compulsive disorder (OCD) over four years: findings from a prospective community study of adolescents and young adults (P.4.a.007)

    Abstract

    European Neuropsychopharmacology, vol. 16, no. Suppl. 4

    DOI: 10.1016/S0924-977X(06)70588-0

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    H.-U. Wittchen, P. Zimmermann, F. Waszak, Agnes Nocon, M. Höfler, R. Lieb

    Pathways into ecstasy use: the role of prior cannabis use and ecstasy availability (P.6.c.007)

    Abstract

    European Neuropsychopharmacology, vol. 16, no. Suppl. 4

    DOI: 10.1016/S0924-977X(06)70686-1

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    Agnes Nocon, H.-U. Wittchen, H. Pfister, M. Höfler, R. Lieb, M. Ising

    Panic and agoraphobia in the first three decades of life

    Abstractband zum Institutssymposium des Max-Planck-Instituts für Psychiatrie (25.-26.07.2006), München

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    Agnes Nocon, H.-U. Wittchen, H. Pfister, M. Höfler, R. Lieb

    Eltern mit Panik und ihre Kinder

    [Abstract]

    Wissenschaftliche Beiträge zum 24. Symposium der Fachgruppe Klinische Psychologie und Psychotherapie der Deutschen Gesellschaft für Psychologie (DGPs) [25.-27.05.2006; Würzburg], Lengerich; Berlin; Bremen; Miami; Riga; Viernheim; Wien; Zagreb

    ISBN: 978-3899673210

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    Agnes Nocon, L. Schwender, M. Höfler, H.-U. Wittchen, R. Lieb

    Panic in parents – panic in children?

    Abstractband zum Institutssymposium des Max-Planck-Instituts für Psychiatrie (27.-28.07.2005), München

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    Agnes Nocon, L. Schwender, M. Höfler, H.-U. Wittchen, R. Lieb

    Panische Eltern – Panische Kinder?

    [Abstract]

    Klinische Psychologie und Psychotherapie 2005, Lengerich

    ISBN: 978-3-89967-220-6

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    R. Lieb, L. Schwender, Agnes Nocon, H. Pfister, H.-U. Wittchen

    The natural course of obsessive compulsive disorder over four years: Findings from a prospective community study of adolescents and young adults

    [Abstract; Poster Session at the 8th ECNP Regional Meeting, Moscow, Russia; June 14-15, 2005]

    European Neuropsychopharmacology, vol. 15, no. Suppl. 2

    DOI: 10.1016/S0924-977X(05)80342-6

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    Agnes Nocon, H.-U. Wittchen

    Kann man von Cannabis eigentlich abhängig werden?

    [Abstract]

    22. Symposium Klinische Psychologie und Psychotherapie, Fachgruppe Klinische Psychologie und Psychotherapie der DGPs (20.-22. Mai 2004; Halle/Saale), Lengerich; Berlin; Bremen; Miami; Riga; Viernheim; Wien; Zagreb

    ISBN: 3-89967-129-5

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    Agnes Nocon, R. Eberle-Sejari, J. Unterhitzenberger, R. Rosner

    The effectiveness of psychosocial interventions in young war-traumatized refugees – systematic review and meta-analysis

    European Journal of Psychotraumatology, vol. 8, no. Sup2

    DOI: 10.1080/20008198.2017.1388709

    Abstract anzeigen

    Background: The United Nations reported that in 2016 over 65 million people worldwide have forcibly left home. Over 50% are children and adolescents; a substantial number has been traumatized and displaced by war. Objective: To provide an overview of the effectiveness of psychosocial interventions in this group we conducted a narrative review and a meta-analysis of intervention studies providing data on posttraumatic stress symptoms (PTSS), depression, anxiety, grief, and general distress. Method: We searched PILOTS, MEDLINE, WoS, Embase, CENTRAL, LILACS, PsycINFO, ASSIA, CSA, and SA for studies on treatment outcomes for war-traumatized displaced children and adolescents. Between-group effect sizes (ES) and pre-post ES were reconstructed for each trial. Overall pre-post ES were calculated using a random effects model. Results: The narrative review covers 23 studies with a variety of treatments. Out of the 35 calculated between-group ES, only six were significant, all compared to untreated controls. Two of them indicated significant adverse effects on symptoms of general distress or depression. When calculating pre-post effect sizes, the positive between-group results of cognitive behavioural therapy (CBT) and interpersonal therapy (IPT) were reproduced and singular other treatments showed significant positive effects. However, the mean pre-post effects for PTSS and depression could not be interpreted due to the high heterogeneity of the included studies (PTSS: ES = 0.78; I2 = 88.6%; depression: ES = 0.35; I2 = 93.1%). Only the mean pre-post effect for seven active CBT treatment groups for depression (ES = 0.30, 95% CI [0.18, 0.43]) was interpretable (Q = 3.3, df = 6, p = .77). Conclusion: Given the large number of children and adolescents displaced by war there were regrettably few treatment studies available, and many of them were of low methodological quality. The effect sizes lagged behind the effects observed in traumatized minors in general, and often were small or non-significant. However, CBT and IPT showed promising results that need further replication.

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    R. Eberle-Sejari, Agnes Nocon, R. Rosner

    Zur Wirksamkeit psychotherapeutischer Interventionen bei jungen Flüchtlingen und Binnenvertriebenen mit posttraumatischen Symptomen – ein systematischer Review

    Kindheit und Entwicklung, vol. 24, no. 3, pp. 156-169

    DOI: 10.1026/0942-5403/a000171

    Abstract anzeigen

    Trotz hoher Zahlen junger Flüchtlinge und der häufig hohen Belastung mit Symptomen einer Posttraumatischen Belastungsstörung (PTBS) gibt es Unsicherheiten über Therapiemöglichkeiten und deren Effektivität in dieser Patientengruppe. Zur Untersuchung der Wirksamkeit unterschiedlicher Interventionen wurde ein systematischer Review durchgeführt. Nach einer Literaturrecherche mit 798 Treffern erfüllten zehn Studien die Einschlusskriterien. Acht Studien konnten signifikante Reduktionen der PTBS-Symptomatik feststellen. Vielversprechend erscheinen dabei folgende Therapien: Narrative Expositionstherapie für Kinder, „Meditation-Relaxation”, Eye Movement Desensitization and Reprocessing und „Rapid-Ed-Therapie”. Aufgrund der dürftigen Studienlage und methodischer Mängel ist eine genauere Empfehlung allerdings schwierig.

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    K. Fodor, J. Unterhitzenberger, C.-Y. Chou, D. Kartal, S. Leistner, M. Milosavljevic, Agnes Nocon, L. Soler, J. White, S. Yoo, E. Alisic

    Is traumatic stress research global? A bibliometric analysis

    European Journal of Psychotraumatology, vol. 5

    DOI: 10.3402/ejpt.v5.23269

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    R. Rosner, Agnes Nocon, M. Olff

    Behandlung der posttraumatischen Belastungsstörung

    PSYCH up2date, vol. 7, no. 5, pp. 301-315

    DOI: 10.1055/s-0033-1349479

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    S. Knappe, K. Beesdo-Baum, Agnes Nocon, H.-U. Wittchen

    Re-examining the differential familial liability of agoraphobia and panic disorder

    Depression and Anxiety, vol. 29, no. 11, pp. 931-938

    DOI: 10.1002/da.21975

    Abstract anzeigen

    BACKGROUND: Controversy surrounds the question of whether agoraphobia (AG) exists as an independent diagnostic entity apart from panic. In favor of this position, AG without panic disorder (PD) in parents was found being unrelated to offsprings' risk for AG or PD, albeit it may enhance the familial transmission of PD (Nocon et al., Depress Anxiety 2008;25:422-434). However, a recent behavioral genetic analysis (Mosing et al., Depress Anxiety 2009;26:1004-1011) found an increased risk for both PD and AG in siblings of those with AG without PD, casting doubt on whether AG exists independently of PD. Convincing evidence for either position notably requires considering also other anxiety disorders to establish the position of AG relative to the panic/anxiety spectrum. METHODS: Familial transmission of panic attacks (PAs), PD, and AG was examined in a 10-year prospective-longitudinal community study of 3,021 adolescents and young adults including completed direct and indirect information on parental psychopathology. Standardized diagnostic assessments using the Munich-Composite International Diagnostic Interview allowed generating exclusive diagnostic groups independent from diagnostic hierarchy rules. RESULTS: Parental PD without AG was associated with an increased risk for PA and PD+AG, but not for PD without AG or AG without PD in offspring. Parental AG without PD was unrelated to the offsprings' risk for PA, exclusive PD or AG, or PD+AG. Findings were largely unaffected by adjustment for other offspring or parental anxiety disorders. CONCLUSIONS: Findings provide further evidence for the independence of AG apart from the PD spectrum.

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    P. Zimmermann, T. Brückl, Agnes Nocon, A. Heck, H. Pfister, E. Binder, M. Uhr, R. Lieb, F. Holsboer, M. Ising

    Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: Results from a 10-year prospective community study

    American Journal of Psychiatry, vol. 168, no. 10, pp. 1107-1116

    DOI: 10.1176/appi.ajp.2011.10111577

    Abstract anzeigen

    Objective: The binding protein FKBP5 is an important modulator of the function of the glucocorticoid receptor, the main receptor of the stress hormone system. This turns the FKBP5 gene into a key candidate for gene-environment interactions, which are considered critical for pathogenesis of stress-related disorders. The authors explored gene-environment interactions between FKBP5 gene variants and adverse life events in predicting the first occurrence of a major depressive episode. Method: The analyses were based on 884 Caucasians in a 10-year prospective community study. At baseline, they were 14–24 years old and did not fulfill criteria for a major depressive episode. The DSM-IV-based Munich Composite International Diagnostic Interview was used to assess adverse life events preceding baseline and major depressive episodes during follow-up. On the basis of previous findings, five single-nucleotide polymorphisms (SNPs) within the FKBP5 gene were selected for genotyping. Results: While the authors did not observe genetic main effects, they found interactions between the five SNPs and traumatic (but not separation) events, with the strongest effect for severe trauma. The effect of trauma on incident major depressive episodes was evident among subjects homozygous for the minor alleles but not subjects with other genotypes. The findings were replicated in the U.K. Environmental Risk Longitudinal Twin Study. Conclusions: These hypothesis-driven results suggest that an interaction between FKBP5 genotype and trauma is involved in the onset of depression. Subjects homozygous for the minor alleles of the investigated FKBP5 SNPs seem to be particularly sensitive to effects of trauma exposure in terms of triggering depression onset.

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    Hochschulschrift

    Agnes Nocon

    Die Stellung der Agoraphobie in modernen diagnostischen Klassifikationssystemen: Beitrag zu einer nosologischen Kontroverse

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    P. Zimmermann, T. Brückl, Agnes Nocon, H. Pfister, R. Lieb, H.-U. Wittchen, F. Holsboer, J. Angst

    Heterogeneity of DSM-IV Major Depressive Disorder as a Consequence of Subthreshold Bipolarity

    Archives of General Psychiatry, vol. 66, no. 12, pp. 1341-1352