Publikationen


Suche nach „[Gesund]“ hat 262 Publikationen gefunden
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    GesundNachhaltigEuropan Campus Rottal-Inn

    Beitrag (Sammelband oder Tagungsband)

    S. Markov, Georg Steckenbauer, Markus Pillmayer, Marcus Herntrei

    Austria: The forest as a touristic landscape

    International Handbook of Forest Therapy

    2019

    ISBN: 978-1-5275-3955-6

    GesundNachhaltigEuropan Campus Rottal-Inn

    Beitrag (Sammelband oder Tagungsband)

    Georg Steckenbauer, R. Weisböck-Erdheim, S. Tischler, C. Pichler, A. Hartl

    Nutzung und Inszenierung natürlicher Ressourcen im Gesundheitstourismus

    Experience Design im Tourismus – eine Branche im Wandel, Wiesbaden

    2019

    ISBN: 978-3-658-24512-2

    DigitalGesundAngewandte InformatikTC Grafenau

    Vortrag

    Gudrun Fischer

    Impulsvortrag MeDiLand

    Digitale Städte Digitale Regionen Kongress, Hanau

    2019

    GesundAngewandte Gesundheitswissenschaften

    Vortrag

    Melanie Kappelmann-Fenzl, C. Gebhardt, A. Matthies, S. Kuphal, M. Rehli, A. Bosserhoff

    C-Jun drives melanoma progression in PTEN wild type melanoma cells

    German Conference on Bioinformatics 2019, Heidelberg

    2019

    GesundAngewandte GesundheitswissenschaftenInstitut Betriebliches Gesundheitsmanagement u. Arbeitssicherheit

    Zeitschriftenartikel

    Stephan Gronwald

    Emotionen bestimmen die Belastung - Die Grenzen isolierter Betrachtungsweisen

    Kommentierung von: Magnon V, Vallet GT, Auxiette C: Sedentary Behavior at Work and Cognitive Functioning: A Systematic Review. Front Public Health 2018;6:239

    Complementary Medicine Research (Journal Club), vol. 26, pp. 56-57

    2019

    DOI: 10.1159/000497030

    GesundAngewandte GesundheitswissenschaftenInstitut Betriebliches Gesundheitsmanagement u. Arbeitssicherheit

    Beitrag (Sammelband oder Tagungsband)

    Stephan Gronwald, Jasmin Weber

    Systemtheoretische Kausalität im modernen Arbeits- und Gesundheitsschutz: Konsequenzen für das Prozessmanagement

    Forschungsbericht 2018/2019 der Technischen Hochschule Deggendorf, Deggendorf

    2019

    GesundAngewandte Gesundheitswissenschaften

    Zeitschriftenartikel

    Stephan Gronwald, Jasmin Weber

    Die Bedürfnisse im Fokus oder wie das (Arbeits-)Leben aus dem Gleichgewicht kommt

    Hochschulmagazin Untertitel, vol. 2019

    2019

    GesundAngewandte Gesundheitswissenschaften

    Zeitschriftenartikel

    Melanie Kappelmann-Fenzl, C. Gebhardt, A. Matthies, S. Kuphal, M. Rehli, A. Bosserhoff

    C-Jun drives melanoma progression in PTEN wild type melanoma cells

    Cell Death & Disease, vol. 10, no. Published: 05 August 2019, Article number: 584 (2019)

    2019

    DOI: 10.1038/s41419-019-1821-9

    Abstract anzeigen

    Due to the critical impact of active AP-1 transcription factors in melanoma, it is important to define their target genes and to identify and ultimately inhibit oncogenic signals. Here we mapped the genome-wide occupancy of the AP-1 family member c-Jun in different melanoma cells and correlated AP-1 binding with transcriptome data to detect genes in melanoma regulated by c-Jun. Our analysis shows that c-Jun supports the malignant phenotype by deregulating genes in cancer-relevant signaling pathways, such as mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K) pathways. Moreover, we demonstrate that the importance of c-Jun depends on melanoma stage and mutation status of the tumor suppressor PTEN. Our study reveals that activation of c-Jun overrules the tumor suppressive effect of PTEN in early melanoma development. These findings help to understand the relevance of c-Jun within cancer pathways in different melanoma cell types, especially in relation to MAPK and PI3K pathways, which are commonly deregulated in melanomas. Consequently, targeting c-Jun in PTEN+ melanoma cells may represent a promising therapeutic strategy to inhibit survival of melanoma cells to prevent the development of a metastatic phenotype.

    GesundAngewandte Gesundheitswissenschaften

    Zeitschriftenartikel

    S. Kaufmann, O. Hoos, T. Kuehl, T. Tietz, D. R. Reim, K. Fehske, Richard Latzel, R. Beneke

    Energetic Profiles of the Yo-Yo Intermittent Recovery Tests 1 and 2

    [Submitted for review]

    Journal of Strength and Conditioning Research

    2019

    GesundAngewandte Gesundheitswissenschaften

    Zeitschriftenartikel

    Melanie Kappelmann-Fenzl, S. Kuphal, R. Krupar, D. Schadendorf, V. Umansky, L. Vardimon, C. Hellerbrand, A. Bosserhoff

    Complex Formation with Monomeric α-Tubulin and Importin 13 Fosters c-Jun Protein Stability and Is Required for c-Jun's Nuclear Translocation and Activity

    Cancers, vol. 11, no. 11, pp. 1-12

    2019

    DOI: 10.3390/cancers11111806

    Abstract anzeigen

    Microtubules are highly dynamic structures, which consist of α- and β-tubulin heterodimers. They are essential for a number of cellular processes, including intracellular trafficking and mitosis. Tubulin-binding chemotherapeutics are used to treat different types of tumors, including malignant melanoma. The transcription factor c-Jun is a central driver of melanoma development and progression. Here, we identify the microtubule network as a main regulator of c-Jun activity. Monomeric α-tubulin fosters c-Jun protein stability by protein-protein interaction. In addition, this complex formation is necessary for c-Jun's nuclear localization sequence binding to importin 13, and consequent nuclear import and activity of c-Jun. A reduction in monomeric α-tubulin levels by treatment with the chemotherapeutic paclitaxel resulted in a decline in the nuclear accumulation of c-Jun in melanoma cells in an experimental murine model and in patients' tissues. These findings add important knowledge to the mechanism of the action of microtubule-targeting drugs and indicate the newly discovered regulation of c-Jun by the microtubule cytoskeleton as a novel therapeutic target for melanoma and potentially also other types of cancer.

    GesundEuropan Campus Rottal-Inn

    Vortrag

    Irmgard Tischner

    Using story completion tasks to explore perceptions about mental health in a work context

    Symposium: More than just a silly story: the exciting potential of Story Completion for qualitative health research.

    Crafting the Future of Qualitative Health Research in a Changing World. 4th Qualitative Health Research Network (QHRN) Conference, London, GB

    2019

    GesundEuropan Campus Rottal-Inn

    Vortrag

    N. Moller, Irmgard Tischner, A. Vossler

    Using Story Completion Tasks to explore perceptions about mental health in a work context

    25th Annual Research Conference of the British Association of Counselling and Psychotherapy (BACP), Belfast, Northern Ireland

    2019

    GesundEuropan Campus Rottal-Inn

    Vortrag

    V. Braun, Irmgard Tischner

    Workshop 3: Story completion for critical health research...

    11th Biennial Conference of the International Society for Critical Health Psychology (ISCHP), Bratislava, Slovakia

    2019

    GesundEuropan Campus Rottal-Inn

    Vortrag

    Irmgard Tischner, M. Ritthaler

    Men, health, masculinity - and pelvic floor exercises

    11th Biennial Conference of the International Society for Critical Health Psychology (ISCHP), Bratislava, Slovakia

    2019

    GesundEuropan Campus Rottal-Inn

    Zeitschriftenartikel

    Irmgard Tischner, H. Malson, K. Fey

    Leading ladies: discursive constructions of women leaders in the UK media

    Feminist Media Studies, no. Published online: 10 July 2019

    2019

    DOI: 10.1080/14680777.2019.1640266

    Abstract anzeigen

    Women continue to be economically disadvantaged and under-represented in positions of power and leadership. A discursive disjunction between cultural and media representations of women and leadership has been implicated in these continuing inequalities. We address this issue through an analysis of the ways in which prominent women leaders were portrayed in a UK radio series, BBC Radio 4’s “Profile” broadcast between July 2011 and July 2013. Verbatim transcripts of 12 broadcasts featuring women were analysed within a critical feminist framework, to explore the ways in which these women leaders were discursively constructed. Our analysis explicates three constructions of “women leaders”: as “traditionally” feminine; as having to balance “masculine” and “feminine” attributes; and as exceptional women who may nevertheless fail. We conclude that the impact of equality legislation continues to be limited while androcentric norms prevail and that we therefore need more gynocentric ways of imagining women leaders.

    GesundAngewandte Gesundheitswissenschaften

    Buch (Monographie)

    Bernhard Bleyer

    Pragmatische Urteile in der unmittelbaren Patientenversorgung

    Moraltheorie an den Anfängen Klinischer Ethikberatung

    Gesundheit und Medizin im interdisziplinären Diskurs, Berlin

    2019

    ISBN: 9783662586723

    GesundAngewandte Gesundheitswissenschaften

    Beitrag (Sammelband oder Tagungsband)

    Bernhard Bleyer

    Bedingungen einer katholischen Moraltheologie in der Wissenschaft

    Die Wissenschaftlichkeit der Theologie: Band 2: Katholische Disziplinen und ihre Wissenschaftstheorien (Studien zur systematischen Theologie, Ethik und Philosophie), Münster, vol. 13/2

    2019

    ISBN: 978-3402119181

    GesundAngewandte Gesundheitswissenschaften

    Zeitschriftenartikel

    L. Feuerer, S. Lamm, I. Henz, Melanie Kappelmann-Fenzl, S. Haferkamp, S. Meierjohann, C. Hellerbrand, S. Kuphal, A. Bosserhoff

    Role of MIA (melanoma inhibitory activity) in melanocyte senescence

    Pigment Cell & Melanoma Research, no. First Published: 06 June 2019

    2019

    DOI: 10.1111/pcmr.12801

    Abstract anzeigen

    The protein MIA is known to be expressed in melanoma and to support melanoma progression. Interestingly, previous studies also observed the expression of MIA in nevi. Concentrating on these findings, we revealed that MIA expression is correlated with a senescent state in melanocytes. Induction of replicative or oncogene‐induced senescence resulted in increased MIA expression in vitro. Notably, MIA‐knockdown in senescent melanocytes reduced the percentage of senescence‐associated beta‐Gal‐positive cells and enhanced proliferation. Using the melanoma mouse model Tg(Grm1), MIA‐deficient mice supported the impact of MIA on senescence by showing a significantly earlier tumor onset compared to controls. In melanocytes, MIA‐knockdown led to a downregulation of the cell cycle inhibitor p21 in vitro and in vivo. In contrast, after induction of hTERT in human melanoma cells, p21 regulation by MIA was lost. In summary, our data show for the first time that MIA is a regulator of cellular senescence in human and murine melanocytes.

    GesundAngewandte GesundheitswissenschaftenEuropan Campus Rottal-Inn

    Vortrag

    Camila Tomikawa

    Visualizing the relations between tumor and immunohistochemical markers

    Posterpräsentation

    6. Tag der Forschung, Deggendorf

    2019

    GesundAngewandte GesundheitswissenschaftenEuropan Campus Rottal-Inn

    Vortrag

    Moustafa Ali

    The orientation of physician about eHealth is not created equal

    Posterpräsentation

    6. Tag der Forschung, Deggendorf

    2019