Kristina Wanieck, P. Fayemi, N. Maranzana, C. Zollfrank, A. Aoussat
Biomimetics: process, tools and practice
Bioinspiration & Biomimetics, vol. 12, no. 1
Biomimetics applies principles and strategies abstracted from biological systems to engineering and technological design. With a huge potential for innovation, biomimetics could evolve into a key process in businesses. Yet challenges remain within the process of biomimetics, especially from the perspective of potential users. We work to clarify the understanding of the process of biomimetics. Therefore, we briefly summarize the terminology of biomimetics and bioinspiration. The implementation of biomimetics requires a stated process. Therefore, we present a model of the problem-driven process of biomimetics that can be used for problem-solving activity. The process of biomimetics can be facilitated by existing tools and creative methods. We mapped a set of tools to the biomimetic process model and set up assessment sheets to evaluate the theoretical and practical value of these tools. We analyzed the tools in interdisciplinary research workshops and present the characteristics of the tools. We also present the attempt of a utility tree which, once finalized, could be used to guide users through the process by choosing appropriate tools respective to their own expertize. The aim of this paper is to foster the dialogue and facilitate a closer collaboration within the field of biomimetics.
Kristina Wanieck, S. Jacobs, P. Fayemi, N. Maranzana, C. Zollfrank
Biomimetics and its Tools
Bioinspired, Biomimetic and Nanobiomaterials, no. January, pp. 1-14
Biomimetics, as the transfer of strategies from biology to technology, is an emerging research area and has led to significant concepts over the past decades. The development of such concepts is described by the process of biomimetics, encompassing several steps. In Practice, beneficiaries of the process face challenges. Therefore, to overcome challenges and to facilitate the steps, tools have been developed in various areas, such as engineering, computing and design. However, these tools are not widely used yet. This paper presents an overview and a classification study of more than 40 tools with qualitative criteria. The criteria included, for example, the year of development, the accessibility of tools, the facilitated steps of the process or their contribution to sustainability. The classification shows that certain steps of the process and their challenges are well addressed by the tools, while other steps are not. The presented results contribute to the proposal of an improvement of the state of the art, and they build the foundation for future theoretical and practical analyses. These findings could contribute to increasing the implementation of biomimetics in various disciplines in the long term.
Die Natur als Vorbild - Intelligenter Leichtbau mit Bionik
KC-aktuell (Das Magazin für Kunststoff und Kooperation), no. 1
Kristina Wanieck, W. Reidt, S. Dukowic-Schulze, H. Puchta, A. Block-Schmidt
BRCC36A is epistatic to BRCA1 in DNA crosslink repair and homologous recombination in Arabidopsis thaliana
Nucleic Acids Research, vol. 39, no. 1, pp. 146-154
BRCA1 is a well-known tumor suppressor protein in mammals, involved in multiple cellular processes such as DNA repair, chromosome segregation and chromatin remodeling. Interestingly, homologs of BRCA1 and several of its complex partners are also found in plants. As the respective mutants are viable, in contrast to mammalian mutants, detailed analyses of their biological role is possible. Here we demonstrate that the model plant Arabidopsis thaliana harbors two homologs of the mammalian BRCA1 interaction partner BRCC36, AtBRCC36A and AtBRCC36B. Mutants of both genes as well as the double mutants are fully fertile and show no defects in development. We were able to show that mutation of one of the homologs, AtBRCC36A, leads to a severe defect in intra- and interchromosomal homologous recombination (HR). A HR defect is also apparent in Atbrca1 mutants. As the Atbrcc36a/Atbrca1 double mutant behaves like the single mutants of AtBRCA1 and AtBRCC36A both proteins seem to be involved in a common pathway in the regulation of HR. AtBRCC36 is also epistatic to AtBRCA1 in DNA crosslink repair. Upon genotoxic stress, AtBRCC36A is transferred into the nucleus.
R. Wurz, H. Chu, Kristina Wanieck, W. Reidt, H. Puchta
A homologue of the breast cancer-associated gene BARD1 is involved in DNA repair in plants
The EMBO Journal, vol. 25, no. 18, pp. 4326-4337
hBRCA1 and hBARD1 are tumor suppressor proteins that are involved as heterodimer via ubiquitinylation in many cellular processes, such as DNA repair. Loss of BRCA1 or BARD1 results in early embryonic lethality and chromosomal instability. The Arabidopsis genome carries a BRCA1 homologue, and we were able to identify a BARD1 homologue. AtBRCA1 and the putative AtBARD1 protein are able to interact with each other as indicated by in vitro and in planta experiments. We have identified T-DNA insertion mutants for both genes, which show no visible phenotype under standard growth conditions and are fully fertile. Thus, in contrast to animals, both genes have no indispensable role during development and meiosis in plants. The two single as well as the double mutant are to a similar extent sensitive to mitomycin C, indicating an epistatic interaction in DNA crosslink repair. We could further demonstrate that in Arabidopsis BARD1 plays a prominent role in the regulation of homologous DNA repair in somatic cells.
Zukunftstechnologie Bionik - Wie die Natur Vorbild sein kann für Produktentwicklung und Innovation
Kolloquium der Fakultät Maschinenbau und Mechatronik, Deggendorf