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Suche nach „[M.] [Ising]“ hat 12 Publikationen gefunden
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    GesundAngewandte Gesundheitswissenschaften

    Zeitschriftenartikel

    P. Zimmermann, T. Brückl, Agnes Nocon, A. Heck, H. Pfister, E. Binder, M. Uhr, R. Lieb, F. Holsboer, M. Ising

    Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: Results from a 10-year prospective community study

    American Journal of Psychiatry, vol. 168, no. 10, pp. 1107-1116

    2011

    DOI: 10.1176/appi.ajp.2011.10111577

    Abstract anzeigen

    Objective: The binding protein FKBP5 is an important modulator of the function of the glucocorticoid receptor, the main receptor of the stress hormone system. This turns the FKBP5 gene into a key candidate for gene-environment interactions, which are considered critical for pathogenesis of stress-related disorders. The authors explored gene-environment interactions between FKBP5 gene variants and adverse life events in predicting the first occurrence of a major depressive episode. Method: The analyses were based on 884 Caucasians in a 10-year prospective community study. At baseline, they were 14–24 years old and did not fulfill criteria for a major depressive episode. The DSM-IV-based Munich Composite International Diagnostic Interview was used to assess adverse life events preceding baseline and major depressive episodes during follow-up. On the basis of previous findings, five single-nucleotide polymorphisms (SNPs) within the FKBP5 gene were selected for genotyping. Results: While the authors did not observe genetic main effects, they found interactions between the five SNPs and traumatic (but not separation) events, with the strongest effect for severe trauma. The effect of trauma on incident major depressive episodes was evident among subjects homozygous for the minor alleles but not subjects with other genotypes. The findings were replicated in the U.K. Environmental Risk Longitudinal Twin Study. Conclusions: These hypothesis-driven results suggest that an interaction between FKBP5 genotype and trauma is involved in the onset of depression. Subjects homozygous for the minor alleles of the investigated FKBP5 SNPs seem to be particularly sensitive to effects of trauma exposure in terms of triggering depression onset.

    GesundAngewandte Gesundheitswissenschaften

    Beitrag (Sammelband oder Tagungsband)

    Agnes Nocon, H. Pfister, M. Rosenhagen, S. Lucae, M. Uhr, M. Ising

    The combined effects of cognitive behavior therapy and pharmacotherapy on emotion-regulation in depressed patients

    Abstractband zum Institutssymposium des Max-Planck-Instituts für Psychiatrie (27.-28.07.2010), München

    2010

    GesundAngewandte Gesundheitswissenschaften

    Zeitschriftenartikel

    P. Zimmermann, T. Brückl, H. Pfister, R. Lieb, H.-U. Wittchen, F. Holsboer, M. Ising, E. Binder, M. Uhr, Agnes Nocon

    The interplay of variations in the FKBP5 gene and adverse life events in predicting the first onset of depression during a ten-year follow-up

    [Congress Abstract; 26th Symposium of the AGNP; Munich; October, 7-10, 2009]

    Pharmacopsychiatry, vol. 42, no. 5

    2009

    GesundAngewandte Gesundheitswissenschaften

    Zeitschriftenartikel

    Agnes Nocon, K. Hackmann, H. Pfister, B. Heldmann, S. Lucae, M. Rosenhagen, M. Ising

    Biomarkers for the combined efficacy of cognitive behavioral therapy in antidepressant treatment in depression

    [Congress Abstract; 26th Symposium of the AGNP]

    Pharmacopsychiatry, vol. 42, no. 5

    2009

    GesundAngewandte Gesundheitswissenschaften

    Zeitschriftenartikel

    Agnes Nocon, K. Hackmann, H. Pfister, B. Heldmann, M. Rosenhagen, S. Lucae, M. Ising

    Biomarkers for the combined efficacy of cognitive behavioural therapy in antidepressant treatment in depression

    [Abstract]

    European Neuropsychopharmacology, vol. 19, no. Supplement 3

    2009

    GesundAngewandte Gesundheitswissenschaften

    Beitrag (Sammelband oder Tagungsband)

    Agnes Nocon, K. Hackmann, H. Pfister, B. Heldmann, M. Rosenhagen, S. Lucae, M. Ising

    Biomarkers for the efficacy of cognitive behavioral therapy in antidepressant treatment in depression

    Abstractband zum Institutssymposium des Max-Planck-Instituts für Psychiatrie (28.-29.07.2009), München

    2009

    GesundAngewandte Gesundheitswissenschaften

    Beitrag (Sammelband oder Tagungsband)

    Agnes Nocon, T. Brückl, P. Zimmermann, H. Pfister, M. Höfler, R. Lieb, H.-U. Wittchen, M. Ising

    Pathways into panic and phobias

    Abstractband zum Institutssymposium des Max-Planck-Instituts für Psychiatrie (29.-30.07.2008), München

    2008

    GesundAngewandte Gesundheitswissenschaften

    Zeitschriftenartikel

    P. Zimmermann, T. Brückl, R. Lieb, Agnes Nocon, M. Ising, K. Beesdo, H.-U. Wittchen

    The interplay of familial depression liability and adverse events in predicting the first onset of depression during a 10-year follow-up

    Biological Psychiatry, vol. 63, no. 4, pp. 406-414

    2008

    DOI: 10.1016/j.biopsych.2007.05.020

    Abstract anzeigen

    BACKGROUND: The aim of the present article is to explore interaction and correlation effects between familial depression liability and selected adverse (separation and traumatic) events in predicting the first onset of a major depressive episode (MDE) in a 10-year prospective longitudinal community survey. METHODS: Analyses are based on 1982 subjects (14 to 24 years at baseline) without baseline MDE who participated during the whole study period and for whom diagnostic information about psychopathology in both parents was available. The offspring's familial depression liability was determined by aggregating information on parental depressive symptoms obtained from family history data and direct interviews with parents. Data were assessed with the Munich-Composite International Diagnostic Interview according to its DSM-IV algorithms. RESULTS: Adverse events predicted a substantially increased incidence of MDE among respondents with familial liability but not in those without familial liability. There was a significant interaction between familial liability and traumatic events with the strongest effect for the number of severe traumatic events (risk difference = 11.3%; 95% confidence interval = 3.55-19.15). Associations with familial liability were most pronounced for separation events. CONCLUSIONS: Adverse events are particularly pathogenic in individuals with familial liability. The involvement of interactions and correlations between familial liability and adversity might depend on type, severity, and number of events. Both processes are suggested to be concomitant rather than exclusive.

    GesundAngewandte Gesundheitswissenschaften

    Zeitschriftenartikel

    T. Brückl, P. Zimmermann, Agnes Nocon, H.-U. Wittchen, R. Lieb, M. Ising

    Birth complications increase the liability for depression according to trauma

    [Abstract]

    Nervenarzt, vol. 78, no. Supplement 2

    2007

    GesundAngewandte Gesundheitswissenschaften

    Beitrag (Sammelband oder Tagungsband)

    T. Brückl, P. Zimmermann, Agnes Nocon, H.-U. Wittchen, R. Lieb, M. Ising

    Exposure to natal complications influences vulnerability for depression under traumatic conditions

    Abstractband zum Institutssymposium des Max-Planck-Instituts für Psychiatrie (24.-25.07.2007), München

    2007

    GesundAngewandte Gesundheitswissenschaften

    Beitrag (Sammelband oder Tagungsband)

    Agnes Nocon, H.-U. Wittchen, K. Beesdo, T. Brückl, M. Hofler, H. Pfister, P. Zimmermann, R. Lieb, M. Ising

    Differential familial liability of panic disorder and agoraphobia

    Abstractband zum Institutssymposium des Max-Planck-Instituts für Psychiatrie (24.-25.07.2007), München

    2007

    GesundAngewandte Gesundheitswissenschaften

    Beitrag (Sammelband oder Tagungsband)

    Agnes Nocon, H.-U. Wittchen, H. Pfister, M. Höfler, R. Lieb, M. Ising

    Panic and agoraphobia in the first three decades of life

    Abstractband zum Institutssymposium des Max-Planck-Instituts für Psychiatrie (25.-26.07.2006), München

    2006