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Suche nach „[H.-U.] [Wittchen]“ hat 26 Publikationen gefunden
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    S. Knappe, Agnes Nocon, K. Beesdo-Baum, H.-U. Wittchen

    Further evidence for the differential familial aggregation of agoraphobia and panic disorder

    [Congress Abstract; 102nd Annual American Psychopathological Association Meeting on “Multigenerational Transmission of Psychopathology"; March 1-3, 2012; New York, NY, USA]

    Comprehensive Psychiatry, vol. 54, no. 1

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    P. Zimmermann, T. Brückl, H. Pfister, R. Lieb, H.-U. Wittchen, F. Holsboer, M. Ising, E. Binder, M. Uhr, Agnes Nocon

    The interplay of variations in the FKBP5 gene and adverse life events in predicting the first onset of depression during a ten-year follow-up

    [Congress Abstract; 26th Symposium of the AGNP; Munich; October, 7-10, 2009]

    Pharmacopsychiatry, vol. 42, no. 5

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    Agnes Nocon, T. Brückl, P. Zimmermann, H. Pfister, M. Höfler, R. Lieb, H.-U. Wittchen, M. Ising

    Pathways into panic and phobias

    Abstractband zum Institutssymposium des Max-Planck-Instituts für Psychiatrie (29.-30.07.2008), München

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    Agnes Nocon, H.-U. Wittchen, K. Beesdo, D. Pine, M. Höfler, R. Lieb, A. Gloster

    Relationship of panic and agoraphobia: rethinking of a diagnostic concept?

    [Abstract]

    European Neuropsychopharmacology, vol. 18, no. Supplement 4

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    Agnes Nocon, T. Brückl, P. Zimmermann, J. Rehm, H. Irving, H. Pfister, M. Höfler, R. Lieb, H.-U. Wittchen

    Pathways into panic and phobias

    [Abstract]

    The International Journal of Neuropsychopharmacology, vol. 11, no. Suppl. 1

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    Agnes Nocon, T. Brückl, P. Zimmermann, R. Lieb, H.-U. Wittchen

    Specific vulnerability and risk factors for the onset of panic disorder, agoraphobia and other phobias

    [Congress Abstract; 25th Symposium of the AGNP; Munich; October, 3-6, 2007]

    Pharmacopsychiatry, vol. 40, no. 5

    Abstract anzeigen

    Background: On the background of the ongoing debate whether agoraphobia is a conditioned reaction to biologically elicited panic attacks as proposed by Donald Klein, or whether agoraphobia is accompanied by panic attacks just like other phobias as suggested by Isaac Marks, we aim to study the common and the specific nature of vulnerability/risk factors of panic disorder [PD], agoraphobia [AG], social [SOC] and specific phobia [SPE]. Method: Analyses are based on 3021 participants from a 10-year prospective-longitudinal community survey (14-24 years old at baseline). Lifetime DSM-IV diagnoses and syndromes were assessed via standardized M-CIDI interview. Vulnerabilities in three domains (socio-demographic, family and behavioral-emotional) were assessed. Results: (1) Subjects with PD, SOC and SP were at higher risk for AG, and subjects with AG and SP were at higher risk for panic attacks/disorder. 2) All syndromes were associated with behavioral inhibition (fear). 3) Only phobias, but not PD, were associated with temperament (harm avoidance), behavioral inhibition (social), gender, parental mood disorder, and separation from parents. 4) Parenting style (rejection) was associated to SOC and SP, but not to AG or PD. Discussion: There is some evidence that phobias (particularly AG and SP) are similar with respect to anxiety comorbidity patterns and associations with socio-demographic, family and behavioral-emotional factors, and that these associations are not accounted for by anxiety comorbidity. Risk factors for PD might be rather unspecific and accounted for by comorbid phobias.

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    T. Brückl, P. Zimmermann, Agnes Nocon, H.-U. Wittchen, R. Lieb, M. Ising

    Birth complications increase the liability for depression according to trauma

    [Abstract]

    Nervenarzt, vol. 78, no. Supplement 2

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    T. Brückl, P. Zimmermann, Agnes Nocon, H.-U. Wittchen, R. Lieb, M. Ising

    Exposure to natal complications influences vulnerability for depression under traumatic conditions

    Abstractband zum Institutssymposium des Max-Planck-Instituts für Psychiatrie (24.-25.07.2007), München

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    Agnes Nocon, H.-U. Wittchen, K. Beesdo, T. Brückl, M. Hofler, H. Pfister, P. Zimmermann, R. Lieb, M. Ising

    Differential familial liability of panic disorder and agoraphobia

    Abstractband zum Institutssymposium des Max-Planck-Instituts für Psychiatrie (24.-25.07.2007), München

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    R. Lieb, L. Schwender, Agnes Nocon, H. Pfister, H.-U. Wittchen

    Natural course of obsessive compulsive disorder (OCD) over four years: findings from a prospective community study of adolescents and young adults (P.4.a.007)

    Abstract

    European Neuropsychopharmacology, vol. 16, no. Suppl. 4

    DOI: 10.1016/S0924-977X(06)70588-0

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    H.-U. Wittchen, P. Zimmermann, F. Waszak, Agnes Nocon, M. Höfler, R. Lieb

    Pathways into ecstasy use: the role of prior cannabis use and ecstasy availability (P.6.c.007)

    Abstract

    European Neuropsychopharmacology, vol. 16, no. Suppl. 4

    DOI: 10.1016/S0924-977X(06)70686-1

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    Agnes Nocon, H.-U. Wittchen, H. Pfister, M. Höfler, R. Lieb, M. Ising

    Panic and agoraphobia in the first three decades of life

    Abstractband zum Institutssymposium des Max-Planck-Instituts für Psychiatrie (25.-26.07.2006), München

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    Agnes Nocon, H.-U. Wittchen, H. Pfister, M. Höfler, R. Lieb

    Eltern mit Panik und ihre Kinder

    [Abstract]

    Wissenschaftliche Beiträge zum 24. Symposium der Fachgruppe Klinische Psychologie und Psychotherapie der Deutschen Gesellschaft für Psychologie (DGPs) [25.-27.05.2006; Würzburg], Lengerich; Berlin; Bremen; Miami; Riga; Viernheim; Wien; Zagreb

    ISBN: 978-3899673210

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    Agnes Nocon, L. Schwender, M. Höfler, H.-U. Wittchen, R. Lieb

    Panic in parents – panic in children?

    Abstractband zum Institutssymposium des Max-Planck-Instituts für Psychiatrie (27.-28.07.2005), München

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    Agnes Nocon, L. Schwender, M. Höfler, H.-U. Wittchen, R. Lieb

    Panische Eltern – Panische Kinder?

    [Abstract]

    Klinische Psychologie und Psychotherapie 2005, Lengerich

    ISBN: 978-3-89967-220-6

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    R. Lieb, L. Schwender, Agnes Nocon, H. Pfister, H.-U. Wittchen

    The natural course of obsessive compulsive disorder over four years: Findings from a prospective community study of adolescents and young adults

    [Abstract; Poster Session at the 8th ECNP Regional Meeting, Moscow, Russia; June 14-15, 2005]

    European Neuropsychopharmacology, vol. 15, no. Suppl. 2

    DOI: 10.1016/S0924-977X(05)80342-6

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    Agnes Nocon, H.-U. Wittchen

    Kann man von Cannabis eigentlich abhängig werden?

    [Abstract]

    22. Symposium Klinische Psychologie und Psychotherapie, Fachgruppe Klinische Psychologie und Psychotherapie der DGPs (20.-22. Mai 2004; Halle/Saale), Lengerich; Berlin; Bremen; Miami; Riga; Viernheim; Wien; Zagreb

    ISBN: 3-89967-129-5

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    S. Knappe, K. Beesdo-Baum, Agnes Nocon, H.-U. Wittchen

    Re-examining the differential familial liability of agoraphobia and panic disorder

    Depression and Anxiety, vol. 29, no. 11, pp. 931-938

    DOI: 10.1002/da.21975

    Abstract anzeigen

    BACKGROUND: Controversy surrounds the question of whether agoraphobia (AG) exists as an independent diagnostic entity apart from panic. In favor of this position, AG without panic disorder (PD) in parents was found being unrelated to offsprings' risk for AG or PD, albeit it may enhance the familial transmission of PD (Nocon et al., Depress Anxiety 2008;25:422-434). However, a recent behavioral genetic analysis (Mosing et al., Depress Anxiety 2009;26:1004-1011) found an increased risk for both PD and AG in siblings of those with AG without PD, casting doubt on whether AG exists independently of PD. Convincing evidence for either position notably requires considering also other anxiety disorders to establish the position of AG relative to the panic/anxiety spectrum. METHODS: Familial transmission of panic attacks (PAs), PD, and AG was examined in a 10-year prospective-longitudinal community study of 3,021 adolescents and young adults including completed direct and indirect information on parental psychopathology. Standardized diagnostic assessments using the Munich-Composite International Diagnostic Interview allowed generating exclusive diagnostic groups independent from diagnostic hierarchy rules. RESULTS: Parental PD without AG was associated with an increased risk for PA and PD+AG, but not for PD without AG or AG without PD in offspring. Parental AG without PD was unrelated to the offsprings' risk for PA, exclusive PD or AG, or PD+AG. Findings were largely unaffected by adjustment for other offspring or parental anxiety disorders. CONCLUSIONS: Findings provide further evidence for the independence of AG apart from the PD spectrum.

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    P. Zimmermann, T. Brückl, Agnes Nocon, H. Pfister, R. Lieb, H.-U. Wittchen, F. Holsboer, J. Angst

    Heterogeneity of DSM-IV Major Depressive Disorder as a Consequence of Subthreshold Bipolarity

    Archives of General Psychiatry, vol. 66, no. 12, pp. 1341-1352

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    H.-U. Wittchen, Agnes Nocon, K. Beesdo, D. Pine, M. Hoefler, R. Lieb, A. Gloster

    Agoraphobia and Panic: Prospective-longitudinal Relations Suggest a Rethinking of Diagnostic Concepts

    Psychotherapy and Psychosomatics, vol. 77, no. 3, pp. 147-157

    DOI: 10.1159/000116608

    Abstract anzeigen

    Background: The relationship of panic attacks (PA), panic disorder (PD) and agoraphobia (AG) is controversial. The aim of the current study is to prospectively examine the 10-year natural course of PA, PD and AG in the first three decades of life, their stability and their reciprocal transitions. Methods: DSM-IV syndromes were assessed via Composite International Diagnostic Interview – Munich version in a 10-year prospective-longitudinal community study of 3,021 subjects aged 14–24 years at baseline. Results: (1) Incidence patterns for PA (9.4%), PD (with and without AG: 3.4%) and AG (5.3%) revealed differences in age of onset, incidence risk and gender differentiation. (2) Temporally primary PA and PD revealed only a moderately increased risk for subsequent onset of AG, and primary AG had an even lower risk for subsequent PA and PD. (3) In strictly prospective analyses, all baseline groups (PA, PD, AG) had low remission rates (0–23%). Baseline PD with AG or AG with PA were more likely to have follow-up AG, PA and other anxiety disorders and more frequent complications (impairment, disability, help-seeking, comorbidity) as compared to PD without AG and AG without PA. Conclusions: Differences in incidence patterns, syndrome progression and outcome, and syndrome stability over time indicate that AG exists as a clinically significant phobic condition independent of PD. The majority of agoraphobic subjects in this community sample never experienced PA, calling into question the current pathogenic assumptions underlying the classification of AG as merely a consequence of panic. The findings point to the necessity of rethinking diagnostic concepts and DSM diagnostic hierarchies.