InformaApp - Publikationen

Vortrag

Psychische Gesundheit junger Flüchtlinge und Implikationen für die Freiwilligenarbeit

2017

Vortrag

Die Effektivität psychosozialer Interventionen bei kriegstraumatisierten jungen Flüchtlingen - systematisches Review und Metaanalyse

19. Jahrestagung der Deutschsprachigen Gesellschaft für Psychotraumatologie (DeGPT) [09.-11.02.2017], Zürich, Schweiz

2017

Agnes Nocon, R. Eberle-Sejari, J. Unterhitzenberger, R. Rosner

Zeitschriftenartikel

The effectiveness of psychosocial interventions in young war-traumatized refugees – systematic review and meta-analysis

European Journal of Psychotraumatology, vol. 8, no. Sup2

2017

DOI: 10.1080/20008198.2017.1388709

Background: The United Nations reported that in 2016 over 65 million people worldwide have forcibly left home. Over 50% are children and adolescents; a substantial number has been traumatized and displaced by war. Objective: To provide an overview of the effectiveness of psychosocial interventions in this group we conducted a narrative review and a meta-analysis of intervention studies providing data on posttraumatic stress symptoms (PTSS), depression, anxiety, grief, and general distress. Method: We searched PILOTS, MEDLINE, WoS, Embase, CENTRAL, LILACS, PsycINFO, ASSIA, CSA, and SA for studies on treatment outcomes for war-traumatized displaced children and adolescents. Between-group effect sizes (ES) and pre-post ES were reconstructed for each trial. Overall pre-post ES were calculated using a random effects model. Results: The narrative review covers 23 studies with a variety of treatments. Out of the 35 calculated between-group ES, only six were significant, all compared to untreated controls. Two of them indicated significant adverse effects on symptoms of general distress or depression. When calculating pre-post effect sizes, the positive between-group results of cognitive behavioural therapy (CBT) and interpersonal therapy (IPT) were reproduced and singular other treatments showed significant positive effects. However, the mean pre-post effects for PTSS and depression could not be interpreted due to the high heterogeneity of the included studies (PTSS: ES = 0.78; I2 = 88.6%; depression: ES = 0.35; I2 = 93.1%). Only the mean pre-post effect for seven active CBT treatment groups for depression (ES = 0.30, 95% CI [0.18, 0.43]) was interpretable (Q = 3.3, df = 6, p = .77). Conclusion: Given the large number of children and adolescents displaced by war there were regrettably few treatment studies available, and many of them were of low methodological quality. The effect sizes lagged behind the effects observed in traumatized minors in general, and often were small or non-significant. However, CBT and IPT showed promising results that need further replication.

Vortrag

The effectiveness of psychosocial interventions in young war-traumatized refugees - systematic review and meta-analysis

ISTSS 32nd Annual Meeting (International Society for Traumatic Stress Studies) [November 10-12, 2016], Dallas, TX, USA

2016

Vortrag

Trauma und Traumafolgestörungen

Informationsveranstaltung für ehrenamtliche Helfer "Seelische Belastungen durch Flucht und Trauma", Eichstätt

2016

R. Eberle-Sejari, Agnes Nocon, R. Rosner

Zeitschriftenartikel

Zur Wirksamkeit psychotherapeutischer Interventionen bei jungen Flüchtlingen und Binnenvertriebenen mit posttraumatischen Symptomen – ein systematischer Review

Kindheit und Entwicklung, vol. 24, no. 3, pp. 156-169

2015

DOI: 10.1026/0942-5403/a000171

Trotz hoher Zahlen junger Flüchtlinge und der häufig hohen Belastung mit Symptomen einer Posttraumatischen Belastungsstörung (PTBS) gibt es Unsicherheiten über Therapiemöglichkeiten und deren Effektivität in dieser Patientengruppe. Zur Untersuchung der Wirksamkeit unterschiedlicher Interventionen wurde ein systematischer Review durchgeführt. Nach einer Literaturrecherche mit 798 Treffern erfüllten zehn Studien die Einschlusskriterien. Acht Studien konnten signifikante Reduktionen der PTBS-Symptomatik feststellen. Vielversprechend erscheinen dabei folgende Therapien: Narrative Expositionstherapie für Kinder, „Meditation-Relaxation”, Eye Movement Desensitization and Reprocessing und „Rapid-Ed-Therapie”. Aufgrund der dürftigen Studienlage und methodischer Mängel ist eine genauere Empfehlung allerdings schwierig.

DOI: 10.3402/ejpt.v5.23269

Zeitschriftenartikel

K. Fodor, J. Unterhitzenberger, C.-Y. Chou, D. Kartal, S. Leistner, M. Milosavljevic, Agnes Nocon, L. Soler, J. White, S. Yoo, E. Alisic

Is traumatic stress research global? A bibliometric analysis

European Journal of Psychotraumatology, vol. 5

2014

Zeitschriftenartikel

S. Knappe, Agnes Nocon, K. Beesdo-Baum, H.-U. Wittchen

Further evidence for the differential familial aggregation of agoraphobia and panic disorder

[Congress Abstract; 102nd Annual American Psychopathological Association Meeting on “Multigenerational Transmission of Psychopathology"; March 1-3, 2012; New York, NY, USA]

Comprehensive Psychiatry, vol. 54, no. 1

2013

Zeitschriftenartikel

Agnes Nocon, S. Jan, R. Rosner

Psychotherapeutic interventions from the western world in war-traumatized children - a metaanalysis

[Congress Abstract; 13th European Conference on Traumatic Stress: Trauma and its clinical pathways; PTSD and beyond; June 6-9, 2013, Bologna, Italy]

European Journal of Psychotraumatology, vol. 55, no. 4

2013

DOI: 10.1055/s-0033-1349479

Zeitschriftenartikel

R. Rosner, Agnes Nocon, M. Olff

Behandlung der posttraumatischen Belastungsstörung

PSYCH up2date, vol. 7, no. 5, pp. 301-315

2013

Zeitschriftenartikel

S. Knappe, K. Beesdo-Baum, Agnes Nocon, H.-U. Wittchen

Re-examining the differential familial liability of agoraphobia and panic disorder

Depression and Anxiety, vol. 29, no. 11, pp. 931-938

2012

DOI: 10.1002/da.21975

BACKGROUND: Controversy surrounds the question of whether agoraphobia (AG) exists as an independent diagnostic entity apart from panic. In favor of this position, AG without panic disorder (PD) in parents was found being unrelated to offsprings' risk for AG or PD, albeit it may enhance the familial transmission of PD (Nocon et al., Depress Anxiety 2008;25:422-434). However, a recent behavioral genetic analysis (Mosing et al., Depress Anxiety 2009;26:1004-1011) found an increased risk for both PD and AG in siblings of those with AG without PD, casting doubt on whether AG exists independently of PD. Convincing evidence for either position notably requires considering also other anxiety disorders to establish the position of AG relative to the panic/anxiety spectrum. METHODS: Familial transmission of panic attacks (PAs), PD, and AG was examined in a 10-year prospective-longitudinal community study of 3,021 adolescents and young adults including completed direct and indirect information on parental psychopathology. Standardized diagnostic assessments using the Munich-Composite International Diagnostic Interview allowed generating exclusive diagnostic groups independent from diagnostic hierarchy rules. RESULTS: Parental PD without AG was associated with an increased risk for PA and PD+AG, but not for PD without AG or AG without PD in offspring. Parental AG without PD was unrelated to the offsprings' risk for PA, exclusive PD or AG, or PD+AG. Findings were largely unaffected by adjustment for other offspring or parental anxiety disorders. CONCLUSIONS: Findings provide further evidence for the independence of AG apart from the PD spectrum.

DOI: 10.1176/appi.ajp.2011.10111577

Zeitschriftenartikel

P. Zimmermann, T. Brückl, Agnes Nocon, A. Heck, H. Pfister, E. Binder, M. Uhr, R. Lieb, F. Holsboer, M. Ising

Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: Results from a 10-year prospective community study

American Journal of Psychiatry, vol. 168, no. 10, pp. 1107-1116

2011

Objective: The binding protein FKBP5 is an important modulator of the function of the glucocorticoid receptor, the main receptor of the stress hormone system. This turns the FKBP5 gene into a key candidate for gene-environment interactions, which are considered critical for pathogenesis of stress-related disorders. The authors explored gene-environment interactions between FKBP5 gene variants and adverse life events in predicting the first occurrence of a major depressive episode. Method: The analyses were based on 884 Caucasians in a 10-year prospective community study. At baseline, they were 14–24 years old and did not fulfill criteria for a major depressive episode. The DSM-IV-based Munich Composite International Diagnostic Interview was used to assess adverse life events preceding baseline and major depressive episodes during follow-up. On the basis of previous findings, five single-nucleotide polymorphisms (SNPs) within the FKBP5 gene were selected for genotyping. Results: While the authors did not observe genetic main effects, they found interactions between the five SNPs and traumatic (but not separation) events, with the strongest effect for severe trauma. The effect of trauma on incident major depressive episodes was evident among subjects homozygous for the minor alleles but not subjects with other genotypes. The findings were replicated in the U.K. Environmental Risk Longitudinal Twin Study. Conclusions: These hypothesis-driven results suggest that an interaction between FKBP5 genotype and trauma is involved in the onset of depression. Subjects homozygous for the minor alleles of the investigated FKBP5 SNPs seem to be particularly sensitive to effects of trauma exposure in terms of triggering depression onset.

Beitrag (Sammelband oder Tagungsband)

Agnes Nocon, H. Pfister, M. Rosenhagen, S. Lucae, M. Uhr, M. Ising

The combined effects of cognitive behavior therapy and pharmacotherapy on emotion-regulation in depressed patients

Abstractband zum Institutssymposium des Max-Planck-Instituts für Psychiatrie (27.-28.07.2010), München

2010

Hochschulschrift

Die Stellung der Agoraphobie in modernen diagnostischen Klassifikationssystemen: Beitrag zu einer nosologischen Kontroverse

2010

Vortrag

Die Rolle der Genetik bei Angst- und Zwangsstörungen

Jahrestagung "Obsessionen, Zwänge, Tics, Verhaltenssüchte...?" der Deutschen Gesellschaft Zwangserkrankungen (DGZ) und der Tourette-Gesellschaft Deutschland (TGD), München

2009

Zeitschriftenartikel

P. Zimmermann, T. Brückl, H. Pfister, R. Lieb, H.-U. Wittchen, F. Holsboer, M. Ising, E. Binder, M. Uhr, Agnes Nocon

The interplay of variations in the FKBP5 gene and adverse life events in predicting the first onset of depression during a ten-year follow-up

[Congress Abstract; 26th Symposium of the AGNP; Munich; October, 7-10, 2009]

Pharmacopsychiatry, vol. 42, no. 5

2009