Suche nach „[A.] [Zimmermann]“ hat 5 Publikationen gefunden

MobilElektrotechnik und Medientechnik

Beitrag (Sammelband oder Tagungsband)

T. Glohr, E. Hasenberger, A. Zimmermann, T. Maier, Gerhard Krump

Untersuchungen zur Betätigungsakustik als Aspekt der Wertigkeit von Bedienelementen im Fahrzeug

Soziotechnische Gestaltung des digitalen Wandels - kreativ, innovativ, sinnhaft, Dortmund

2017

ISBN: 978-3-936804-22-5

Elektrotechnik und Medientechnik

Vortrag

Diarra Aboubacar, A. Zimmermann, Andreas Grzemba

Improved Clock Synchronization Start-Up Time for Switched Ethernet-Based In-Vehicle Networks

IEEE International Conference on Emerging Technology & Factory Automation (ETFA) 2015, Luxemburg

2015

DigitalElektrotechnik und Medientechnik

Beitrag (Sammelband oder Tagungsband)

Diarra Aboubacar, A. Zimmermann, Andreas Grzemba

Improved Clock Synchronization Start-Up Time for Switched Ethernet-Based In-Vehicle Networks

IEEE International Conference on Emerging Technology & Factory Automation (ETFA) 2015, Luxemburg, pp. 1-8

2015

GesundAngewandte Gesundheitswissenschaften

Zeitschriftenartikel

P. Zimmermann, T. Brückl, Agnes Nocon, A. Heck, H. Pfister, E. Binder, M. Uhr, R. Lieb, F. Holsboer, M. Ising

Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: Results from a 10-year prospective community study

American Journal of Psychiatry, vol. 168, no. 10, pp. 1107-1116

2011

DOI: 10.1176/appi.ajp.2011.10111577

Abstract anzeigen

Objective: The binding protein FKBP5 is an important modulator of the function of the glucocorticoid receptor, the main receptor of the stress hormone system. This turns the FKBP5 gene into a key candidate for gene-environment interactions, which are considered critical for pathogenesis of stress-related disorders. The authors explored gene-environment interactions between FKBP5 gene variants and adverse life events in predicting the first occurrence of a major depressive episode. Method: The analyses were based on 884 Caucasians in a 10-year prospective community study. At baseline, they were 14–24 years old and did not fulfill criteria for a major depressive episode. The DSM-IV-based Munich Composite International Diagnostic Interview was used to assess adverse life events preceding baseline and major depressive episodes during follow-up. On the basis of previous findings, five single-nucleotide polymorphisms (SNPs) within the FKBP5 gene were selected for genotyping. Results: While the authors did not observe genetic main effects, they found interactions between the five SNPs and traumatic (but not separation) events, with the strongest effect for severe trauma. The effect of trauma on incident major depressive episodes was evident among subjects homozygous for the minor alleles but not subjects with other genotypes. The findings were replicated in the U.K. Environmental Risk Longitudinal Twin Study. Conclusions: These hypothesis-driven results suggest that an interaction between FKBP5 genotype and trauma is involved in the onset of depression. Subjects homozygous for the minor alleles of the investigated FKBP5 SNPs seem to be particularly sensitive to effects of trauma exposure in terms of triggering depression onset.

GesundAngewandte Gesundheitswissenschaften

Zeitschriftenartikel

A. Perkonigg, H.-U. Wittchen, P. Zimmermann, Agnes Nocon, A. Settele, B. Spiegel, G. Bühringer, R. Lieb

Grundlagen und Forschungsstrategien regionaler Bedarfs- und Allokationsprozesse am Beispiel des ASAT-F1-Projektes

Suchtmedizin, vol. 6, no. 1, pp. 14-21

2004