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Suche nach „[A.] [Matthies]“ hat 2 Publikationen gefunden
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    GesundAngewandte Gesundheitswissenschaften

    Vortrag

    Melanie Kappelmann-Fenzl, C. Gebhardt, A. Matthies, S. Kuphal, M. Rehli, A. Bosserhoff

    C-Jun drives melanoma progression in PTEN wild type melanoma cells

    German Conference on Bioinformatics 2019, Heidelberg

    2019

    GesundAngewandte Gesundheitswissenschaften

    Zeitschriftenartikel

    Melanie Kappelmann-Fenzl, C. Gebhardt, A. Matthies, S. Kuphal, M. Rehli, A. Bosserhoff

    C-Jun drives melanoma progression in PTEN wild type melanoma cells

    Cell Death & Disease, vol. 10, no. Published: 05 August 2019, Article number: 584 (2019)

    2019

    DOI: 10.1038/s41419-019-1821-9

    Abstract anzeigen

    Due to the critical impact of active AP-1 transcription factors in melanoma, it is important to define their target genes and to identify and ultimately inhibit oncogenic signals. Here we mapped the genome-wide occupancy of the AP-1 family member c-Jun in different melanoma cells and correlated AP-1 binding with transcriptome data to detect genes in melanoma regulated by c-Jun. Our analysis shows that c-Jun supports the malignant phenotype by deregulating genes in cancer-relevant signaling pathways, such as mitogen-activated protein kinase (MAPK) and phosphatidylinositol-3-kinase (PI3K) pathways. Moreover, we demonstrate that the importance of c-Jun depends on melanoma stage and mutation status of the tumor suppressor PTEN. Our study reveals that activation of c-Jun overrules the tumor suppressive effect of PTEN in early melanoma development. These findings help to understand the relevance of c-Jun within cancer pathways in different melanoma cell types, especially in relation to MAPK and PI3K pathways, which are commonly deregulated in melanomas. Consequently, targeting c-Jun in PTEN+ melanoma cells may represent a promising therapeutic strategy to inhibit survival of melanoma cells to prevent the development of a metastatic phenotype.